Santos, J.V.Padron-Monedero, A.Bikbov, B.Grad, D.A.Plass, D.Mechili, E.A.Gazzelloni, F.Fischer, F.Sulo, G.Ngwa, C.H.Noguer-Zambrano, I.Penalvo, J.L.Haagsma, J.A.Kissimova-Skarbek, K.Monasta, L.Ghith, N.Sarmiento-Suarez, R.Hrzic, R.Haneef, R.O'Caoimh, R.et al.2024-10-152024-10-152024BMC Public Health, 2024; 24(1):1374-1-1374-191471-24581471-2458https://hdl.handle.net/2440/142819Background The European Union (EU) faces many health-related challenges. Burden of diseases information and the resulting trends over time are essential for health planning. This paper reports estimates of disease burden in the EU and individual 27 EU countries in 2019, and compares them with those in 2010. Methods We used the Global Burden of Disease 2019 study estimates and 95% uncertainty intervals for the whole EU and each country to evaluate age-standardised death, years of life lost (YLLs), years lived with disability (YLDs) and disability-adjusted life years (DALYs) rates for Level 2 causes, as well as life expectancy and healthy life expectancy (HALE). Results In 2019, the age-standardised death and DALY rates in the EU were 465.8 deaths and 20,251.0 DALYs per 100,000 inhabitants, respectively. Between 2010 and 2019, there were signifcant decreases in age-standardised death and YLL rates across EU countries. However, YLD rates remained mainly unchanged. The largest decreases in age-standardised DALY rates were observed for“HIV/AIDS and sexually transmitted diseases” and“transport injuries” (each -19%). “Diabetes and kidney diseases” showed a signifcant increase for age-standardised DALY rates across the EU (3.5%). In addition, “mental disorders” showed an increasing age-standardised YLL rate (14.5%). Conclusions There was a clear trend towards improvement in the overall health status of the EU but with difer‑ ences between countries. EU health policymakers need to address the burden of diseases, paying specifc attention to causes such as mental disorders. There are many opportunities for mutual learning among otherwise similar coun‑ tries with diferent patterns of disease.en© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecom‑ mons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.European Union; Health status; Population health; Global Burden of Diseases; European Burden of Disease NetworkHumansLife ExpectancyHealth StatusCost of IllnessEuropean UnionFemaleMaleGlobal Burden of DiseaseDisability-Adjusted Life YearsJournal article10.1186/s12889-024-18529-32024-10-15698020Baune, B.T. [0000-0001-6548-426X]Klugar, M. [0000-0002-2804-7295]