Huang, D.M.Chandler, D.2014-11-202021-03-292014-11-202021-03-292000Proceedings of the National Academy of Sciences of USA, 2000; 97(15):8324-83270027-84241091-6490http://hdl.handle.net/2440/129941The Lum–Chandler–Weeks theory of hydrophobicity [Lum, K., Chandler, D. & Weeks, J. D. (1999) J. Phys. Chem. 103, 4570–4577] is applied to treat the temperature dependence of hydrophobic solvation in water. The application illustrates how the temperature dependence for hydrophobic surfaces extending less than 1 nm differs significantly from that for surfaces extending more than 1 nm. The latter is the result of water depletion, a collective effect, that appears at length scales of 1 nm and larger. Because of the contrasting behaviors at small and large length scales, hydrophobicity by itself can explain the variable behavior of entropies of protein folding.enCopyright © The National Academy of SciencesSolutionsTemperatureEnergy TransferProtein FoldingJournal article003000944310.1073/pnas.1201763970000882739000272-s2.0-0034682487107721Huang, D.M. [0000-0003-2048-4500]