Mickan, S.Menikh, A.Liu, H.Mannella, C.MacColl, R.Abbott, D.Munch, J.Zhang, X.2006-06-192006-06-192002Physics in Medicine and Biology, 2002; 47(21):3789-37950031-91551361-6560http://hdl.handle.net/2440/2470© 2002 IOP PublishingWe report the first use of differential terahertz time-domain spectroscopy for bioaffinity sensing. Binding is observed by measuring the transmission of a thin layer of biotin bound to the sensor protein avidin. We demonstrate the THz wave transmission of a sub-micron-thick film and sensitivity to 0.1 µg cm−2 of biotin. These results point the way for a host of biosensor applications using T-rays, or pulsed far-infrared (FIR) radiation.enMacromolecular SubstancesAvidinAffinity LabelsMembranes, ArtificialSensitivity and SpecificityRefractometrySpectrum AnalysisBiosensing TechniquesProtein BindingBiotinElectromagnetic PhenomenaSurface PropertiesMicrowavesEquipment DesignJournal article002002173910.1088/0031-9155/47/21/3170001794253000182-s2.0-003703849259703Abbott, D. [0000-0002-0945-2674]