Ong, J.Kerr, D.Vaccher, C.Berthelot, P.2006-06-232006-06-231997European Journal of Pharmacology, 1997; 329(2-3):133-1360014-29991879-0712http://hdl.handle.net/2440/5993Short communicationIn rat neocortical slices maintained in Mg2+-free Krebs medium, baclofen and its thienyl analogs, 4-amino-3-(5-chlorothien-2-yl)-butanoic acid (5h), 4-amino-3-(5-methylthien-2-yl)-butanoic acid (5d), 4-amino-3-(5-bromothien-2-yl)-butanoic acid (5f) and 4-amino-3-(thien-3-yl)-butanoic acid (5j) dose-dependently suppressed the spontaneous discharges, antagonised by the GABA(B) receptor antagonist 2-hydroxysaclofen (200 microM). Their relative potencies were baclofen > 5h > 5d > 5f > 5j. These heterocyclic analogs may prove useful as GABA(B) receptor agonists in functional studies.en© 1997 Elsevier Science B.V.Baclofen: GABAB receptor agonistThienyl baclofen analog2-HydroxysaclofenNeocortical slice, ratActions of thienyl analogs of baclofen at GABAB receptors in rat neocortical slicesActions of thienyl analogs of baclofen at GABA(B) receptors in rat neocortical slicesJournal article0030006077001997067610.1016/S0014-2999(97)00185-42-s2.0-003092643670083Ong, J. [0000-0002-0958-460X]