Rudkin, A.Edussuriya, K.Sennanayake, S.Senaratne, T.Selva-Nayagam, D.Sullivan, T.Casson, R.2009-11-092009-11-092008British Journal of Ophthalmology, 2008; 92(12):1595-15980007-11611468-2079http://hdl.handle.net/2440/52357Aims: To report the prevalence and correlates of exfoliation syndrome (XFS) in central, rural Sri Lanka. Methods: A population-based, cross-sectional ophthalmic survey of inhabitants 40 years of age and over from villages in the Kandy District was conducted. Selection was randomised using a cluster sampling process. 1721 eligible participants were identified, 1375 participated. A detailed ophthalmic history and examination including ocular biometry was made of each participant. Results: The prevalence of XFS was estimated to be 1.1% (95% CI 0.5 to 1.5%; 22 eyes). XFS was bilateral in eight subjects, unilateral in six subjects. Univariate analysis demonstrated a significant association between XFS and increasing age (p<0.001), increasing intraocular pressure (odds ratio 1.2; 95% CI 1.09 to 1.27; p<0.001), nuclear cataracts (odds ratio 1.92; 95% CI 1.47 to 2.51; p<0.001), visual impairment (odds ratio 9.72; 95% CI 3.01 to 31.44; p<0.001) and a history of hypertension (odds ratio 3.89; 95% CI 1.14 to 13.16; p = 0.030). Conclusion: XFS in this Sri Lankan population was associated with advanced age, raised intraocular pressure, nuclear cataracts, hypertension and visual impairment.enHumansOptic Nerve DiseasesGlaucomaExfoliation SyndromeDisease ProgressionPrevalenceCross-Sectional StudiesAge FactorsBiometryIntraocular PressureAdultAgedMiddle AgedRural HealthSri LankaFemaleMaleJournal article002008405310.1136/bjo.2008.1464070002612225000072-s2.0-5714910213840981Rudkin, A. [0000-0003-2508-8574]Selva-Nayagam, D. [0000-0002-2169-5417]Sullivan, T. [0000-0002-6930-5406]Casson, R. [0000-0003-2822-4076]