Whitelaw, M.Peet, D.Karttunen, S.Lando, D.Gorman, J.A.P.T. Patent and Trade Mark Attorneys2012-12-182012-12-182009http://hdl.handle.net/2440/74681PATENT: M. L. Whitelaw, D. J. Peet, S. Karttunen, J. J. Gorman, D. J. Lando (Assigned to Adelaide Research and Innovation Pty Ltd). AU 2002/331444 B2 (WO03/025013) filed Sep 18, 2002; published Jun 5, 2003; accepted journal date Mar 5, 2009A target asparagine residue of HIF 1 alpha and 2 alpha is hydroxylated at high oxygen tension to render HIF as a weak transcription factor. An asparagine hydroxylase hydroxylation motif and binding motif is proposed. A method of screening for agonists or antagonists of an asparagine hydroxylase is also proposed and involves mixing peptides or proteins having the hydroxylation and or the binding motif with asparagine hydroxylase and a candidate agonist or antagonist. The extent of inhibition or enhancement of binding; level of asparagine hydroxylation or transactivation may be measured depending on the nature of the protein or peptide. Additionally altered proteins resistant to hydroxylation are described as are nucleic acids encoding such proteins.enAU 2002/331444 B2Patent0020114451200233144426965Peet, D. [0000-0002-6085-8936]