Bachhuka, A.Hayball, J.Smith, L.Vasilev, K.2017-05-032017-05-032015ACS Applied Materials and Interfaces, 2015; 7(42):23767-237751944-82441944-8252http://hdl.handle.net/2440/104845Surface modification has been identified as an important technique that could improve the response of the body to implanted medical devices. Collagen production by fibroblasts is known to play a vital role in wound healing and device fibrous encapsulation. However, how surface chemistry affects collagen I and III deposition by these cells has not been systematically studied. Here, we report how surface chemistry influences the deposition of collagen I and III by primary human dermal fibroblasts. Amine (NH3), carboxyl acid (COOH), and hydrocarbon (CH3) surfaces were generated by plasma deposition. This is a practically relevant tool to deposit a functional coating on any type of substrate material. We show that fibroblasts adhere better and proliferate faster on amine-rich surfaces. In addition, the initial collagen I and III production is greater on this type of coating. These data indicates that surface modification can be a promising route for modulating the rate and level of fibrous encapsulation and may be useful in informing the design of implantable biomedical devices to produce more predictable clinical outcomes.en© 2015 American Chemical Societyplasma polymerization; surface chemistry; collagen I; collagen III; fibroblastsJournal article003006872910.1021/acsami.5b082490003639947000492-s2.0-84945932374290644Bachhuka, A. [0000-0003-1253-8126]Hayball, J. [0000-0002-3089-4506]