Freeman, Craig2006-12-282006-12-2819911991http://hdl.handle.net/2440/19747Copies of author's previously published articles insertedIncludes bibliographic references2 v. (various foliations) : ill ; 30 cm.Summary: Studies the enzymology of some of the nine lysosomal exo-enzyme activities which act together to degrade the more highly sulphated regions of the glycosaminoglycans heparin and heparan sulphate. A deficiency of any one of these enzyme activities can result in one of the lysosomal storage disorders collectively known as the Mucopolysaccharidoses (MPS)145878 bytesapplication/pdfen574.87/4616.3/9 20Lysosomes.Enzymes Synthesis.Enzyme activation.Metabolism, Inborn errors of.Glycosaminoglycans Metabolism.Lysosomal storage diseases.Thesis