Wong, S.Haqshenas, G.Gowans, E.MacKenzie, J.2013-03-182013-03-182012FEBS Letters, 2012; 586(7):1032-10370014-57931873-3468http://hdl.handle.net/2440/76007The dengue virus membrane (M) protein is a key component of the mature virion. Here, we characterised the cellular behaviour of M using a recombinant protein construct to understand its inherent properties. Using confocal microscopy, we showed that M and its intracellular precursor, prM, localised to the endoplasmic reticulum. M protein was also detected on the cell surface and secreted, suggesting that M can enter the secretory pathway. In addition, cross-linking studies showed that M can form dimers and tetramers. These findings suggest that M behaves as a secretory protein analogous to the major envelope protein E.enCrown Copyright © 2012 Published by Elsevier B.V. on behalf of Federation of European Biochemical society. All rights reserved.DenguePrMM ProteinLocalisationEndoplasmic reticulumOligomerisationJournal article002011819010.1016/j.febslet.2012.02.0470003022684000152-s2.0-8485926646424986Gowans, E. [0000-0002-4274-8311]