The structures of the frenatin peptides from the skin secretion of the giant tree frog litoria infrenata

Raferty, M.Waugh, R.Bowie, J.Wallace, J.Tyler, M.2006-07-052006-07-051996Journal of Peptide Science, 1996; 2(2):117-1241075-26171099-1387http://hdl.handle.net/2440/11343The granular dorsal glands of the giant tree frog Litoria infrafrenata contain five peptides including caerulein (a known neuropeptide), and four new peptides named frenatins 1 (MH+ = 1140 Da), 2 (1423), 3 (2180) and 4 (2493). The amino acid sequences of the frenatins are detailed: their structures do not correspond to those of peptides isolated from other amphibians or animals. Frenatin 3, Gly-Leu-Met-Ser-Val-Leu-Gly-His-Ala-Val-Gly-Asn-Val-Leu-Gly- Gly-Leu-Phe-Lys-Pro-Lys-Ser-(OH), has wide spectrum antimicrobial properties.en© 1996 European Peptide Society and John Wiley & Sons, Ltd.peptidesneuropeptideantimicrobial agentskin secretionfrogsThe structures of the frenatin peptides from the skin secretion of the giant tree frog litoria infrenataJournal article0030004375001996541910.1002/psc.600002090244000042-s2.0-003008986768381