Forbes, B.A.P.T. Patent and Trade Mark Attorneys2012-12-182012-12-182008http://hdl.handle.net/2440/74687PATENT: B. E. Forbes (Assignee: The University of Adelaide). NZ 537556 (PCT/AU2003/000898) filed Jan. 10, 2005; published Jul. 31, 2008; expires Jul. 11, 2023Disclosed are altered Insulin-like Growth Factor Binding Protein molecules able to effect binding of IGF-I or IGF-II with high affinity characterised in having an inhibited release of IGF on contact with extracellular matrix and exposure to a protease. Also disclosed are nucleic acids encoding the altered IGFBP molecules, a host cell carrying that nucleic acid, and methods of reducing IGF mediated proliferation of a population of cancerous cells.enNZ 537556Patent002011447653755626946