Malik, A.O.Poghni Peri-Okonny,Gosch, K.Thomas, M.B.Mena-Hurtado, C.Hiatt, W.Aronow, H.D.Jones, P.G.Provance, J.Labrosciano, C.Jelani, Q.U.A.Spertus, J.A.Smolderen, K.G.2025-07-222025-07-222021Journal of Psychosomatic Research, 2021; 140:110313-1-110313-70022-39991879-1360https://hdl.handle.net/2440/146212Objective: To assess association of chronic self-perceived stress with health status outcomes of patients with peripheral artery disease. Methods: The PORTRAIT study is a prospective registry that enrolled 1275 patients with symptoms of peripheral artery disease across 16-sites in US, Netherlands, and Australia from June 2011 to December 2015. Demographics, comorbidities and diagnostic information was abstracted from chart review. Self-perceived stress was assessed using the 4-item perceived stress scale at baseline, 3- and 6-month follow-up. Scores range from 0 to 16 with higher scores indicating greater stress. Sum scores were calculated at each time point and averaged to quantify average exposure to stress from enrollment through 6 months. Disease-specific health status were assessed at baseline and 12-months using the peripheral artery disease questionnaire summary score. Results: The mean age of the analytical cohort (n = 1060) was 67.7 ± 9.3 years, 37.1% were females, and 82.3% were white. Comorbidities were highly prevalent with 80.9% having hypertension, 32.6% having diabetes, and 36.4% being smokers. In models adjusted for demographics, comorbidities, disease severity and socioeconomic status, having a higher average stress score was associated with poorer recovery (from baseline) in peripheral artery disease questionnaire summary score at 12-months (— 1.4 points per +1-point increase in averaged 4-point perceived stress score, 95% CI -2.1, — 0.6 p < 0.001). Conclusion: In patients with peripheral artery disease, experiencing higher chronic stress throughout the 6- months following their diagnosis, was independently associated with poorer recovery in 12-month diseasespecific health status outcomes. (ClinicalTrial.gov identifier: NCT01419080).en© 2020 Elsevier Inc. All rights reserved.Chronic stress; Health status; Peripheral artery diseaseHumansSeverity of Illness IndexRegistriesCohort StudiesProspective StudiesStress, PsychologicalHealth StatusAgedFemaleMalePeripheral Arterial DiseaseJournal article10.1016/j.jpsychores.2020.110313559508Labrosciano, C. [0000-0001-5995-4616]Spertus, J.A. [0000-0001-9485-0652] [0000-0002-2839-2611]