Andersson, P.McGuire, J.Rubio, C.Gradin, K.Whitelaw, M.Pettersson, S.Hanberg, A.Poellinger, L.2007-05-112007-05-112002Proceedings of the National Academy of Sciences of USA, 2002; 99(15):9990-99950027-84241091-6490http://hdl.handle.net/2440/28127Published online before print July 9, 2002The dioxin/aryl hydrocarbon receptor (AhR) functions as a ligand-activated transcription factor regulating transcription of a battery of genes encoding xenobiotic metabolizing enzymes. Known receptor ligands are environmental pollutants including polycyclic aromatic hydrocarbons and polychlorinated dioxins. Loss-of-function (gene-disruption) studies in mice have demonstrated that the AhR is involved in toxic effects of dioxins but have not yielded unequivocal results concerning the physiological function of the receptor. Gain-of-function studies therefore were performed to unravel the biological functions of the AhR. A constitutively active AhR expressed in transgenic mice reduced the life span of the mice and induced tumors in the glandular part of the stomach, demonstrating the oncogenic potential of the AhR and implicating the receptor in regulation of cell proliferation.enCopyright © 2002 by the National Academy of SciencesLiverThymus GlandCHO CellsAnimalsMice, Inbred C57BLMice, Inbred CBAMiceIntestinal NeoplasmsStomach NeoplasmsCytochrome P-450 CYP1A1Receptors, Aryl HydrocarbonRecombinant ProteinsCarcinogensCloning, MolecularTransfectionGene Expression Regulation, DevelopmentalCricetinaeMalePolychlorinated DibenzodioxinsJournal article002002001810.1073/pnas.1527062990001770424000712-s2.0-003716252960683