Barthelson, K.Newman, M.Lardelli, M.2023-12-122023-12-122020Journal of Alzheimer's Disease Reports, 2020; 4(1):123-1402542-48232542-4823https://hdl.handle.net/2440/140171Sortilin-related receptor 1 (SORL1) encodes a large, multi-domain containing, membrane-bound receptor involved in endosomal sorting of proteins between the trans-Golgi network, endosomes and the plasma membrane. It is genetically associated with Alzheimer's disease (AD), the most common form of dementia. SORL1 is a unique gene in AD, as it appears to show strong associations with the common, late-onset, sporadic form of AD and the rare, early-onset familial form of AD. Here, we review the genetics of SORL1 in AD and discuss potential roles it could play in AD pathogenesis.en© 2020 – IOS Press and the authors. All rights reserved This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC 4.0).Alzheimer’s diseaseamyloidamyloid-beta protein precursorendocytosisendosomesprotein transportJournal article10.3233/ADR-2001772023-12-12537040Barthelson, K. [0000-0002-4693-8833]Newman, M. [0000-0002-4930-4529]Lardelli, M. [0000-0002-4289-444X]