Suganuma, H.Collins, C.T.McPhee, A.J.Liu, G.Gibson, R.A.2020-01-272020-01-272019Journal of Pediatric Gastroenterology and Nutrition, 2019; 69(2):231-2340277-21161536-4801http://hdl.handle.net/2440/122917Lipid emulsions used to support nutrition in preterm infants contain long-chain polyunsaturated fatty acids (LCPUFAs) as a source of essential fatty acids; these LCPUFAs and their parent polyunsaturated fatty acid (PUFA) can be oxidized by a variety of mechanisms to bioactive molecules called oxylipins, which are signaling molecules that initiate and/or resolve inflammation. The aim of this study was to explore levels of free LCPUFA and their related oxylipins in 3 commercially available lipid emulsions (Intralipid, SMOFlipid, and ClinOleic) using ultra high-performance liquid chromatography mass spectroscopy. Free LCPUFA were detected in all lipid emulsions tested. Seven, 8, and 9 different oxylipin compounds were detected in the 3 emulsions, respectively. The oxylipins detected were mainly derived from omega-6 PUFAs; these included 13-hydroxyoctadecadienoic acid from linoleic acid and 5-hydroxyeicosatetraenoic acid derived from arachidonic acid. It may be clinically important to know that oxylipins exist in lipid emulsions and to evaluate their potential effects on preterm infants.en© 2019 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and NutritionArachidonic acid; linoleic acid; oxidation; polyunsaturated fatty acidJournal article003011387710.1097/mpg.00000000000023690005011455000252-s2.0-85075418809470676Suganuma, H. [0000-0002-4555-5187] [0000-0003-2961-034X]Collins, C.T. [0000-0003-3308-9948]McPhee, A.J. [0000-0003-3820-5696]Gibson, R.A. [0000-0002-8750-525X]