Hart, N.H.Wallen, M.P.Farley, M.J.Haywood, D.Boytar, A.N.Secombe, K.Joseph, R.Chan, R.J.Kenkhuis, M.F.Buffart, L.M.Skinner, T.L.Wardill, H.R.2024-01-232024-01-232023Supportive Care in Cancer, 2023; 31(12):724-1-724-240941-43551433-7339https://hdl.handle.net/2440/140379Purpose: Growing recognition of the gut microbiome as an infuential modulator of cancer treatment efcacy and toxicity has led to the emergence of clinical interventions targeting the microbiome to enhance cancer and health outcomes. The highly modifable nature of microbiota to endogenous, exogenous, and environmental inputs enables interventions to promote resilience of the gut microbiome that have rapid efects on host health, or response to cancer treatment. While diet, probiotics, and faecal microbiota transplant are primary avenues of therapy focused on restoring or protecting gut function in people undergoing cancer treatment, the role of physical activity and exercise has scarcely been examined in this population. Methods: A narrative review was conducted to explore the nexus between cancer care and the gut microbiome in the context of physical activity and exercise as a widely available and clinically efective supportive care strategy used by cancer survivors. Results: Exercise can facilitate a more diverse gut microbiome and functional metabolome in humans; however, most physical activity and exercise studies have been conducted in healthy or athletic populations, primarily using aerobic exercise modalities. A scarcity of exercise and microbiome studies in cancer exists. Conclusions: Exercise remains an attractive avenue to promote microbiome health in cancer survivors. Future research should elucidate the various infuences of exercise modalities, intensities, frequencies, durations, and volumes to explore doseresponse relationships between exercise and the gut microbiome among cancer survivors, as well as multifaceted approaches (such as diet and probiotics), and examine the influences of exercise on the gut microbiome and associated symptom burden prior to, during, and following cancer treatment.en© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023Physical activity; Aerobic; Resistance; Microbiota; Immune system; Supportive careHumansNeoplasmsExerciseDietSportsProbioticsGastrointestinal MicrobiomeJournal article10.1007/s00520-023-08183-72023-12-10678567Secombe, K. [0000-0003-0716-238X]Wardill, H.R. [0000-0002-6613-3661]