Xie, L.Nguyen, L.V.Ebendorff-Heidepriem, H.Warren-Smith, S.2020-01-132020-01-132019IEEE Sensors Journal, 2019; 19(22):10425-104311530-437X1558-1748http://hdl.handle.net/2440/122659A multiplexed fiber sensor is proposed based on Fabry-Perot interferometers formed by serially splicing C-shaped and single mode fibers. We first demonstrate multiplexed refractive index sensing by independently filling and measuring sodium chloride (NaCl) solutions with different concentrations in a two-cavity system. The results show minimal cross-talk between the two interferometers. The dual-cavity interferometric sensor was then applied to biochemical sensing by utilizing polyelectrolyte layer by layer self-assembly followed by the biotin-streptavidin binding mechanism. The proposed sensor solves an important problem in biochemical sensing by providing an ability to simultaneously measure a negative control, critical for reducing false positive measurements.en© 2019 IEEE. Personal use is permitted, but republication/redistribution requires IEEE permission. See http://www.ieee.org/publications_standards/publications/rights/index.html for more information.Biochemical sensing; C-shaped fiber; Fabry-Perot interferometers; optical fiber sensingJournal article100000417910.1109/JSEN.2019.29319400005033992000312-s2.0-85073877574503891Xie, L. [0000-0002-0807-6419]Nguyen, L.V. [0000-0002-2543-2374]Ebendorff-Heidepriem, H. [0000-0002-4877-7770]Warren-Smith, S. [0000-0002-2612-6344]