Olatunji, O.More, A.2025-10-272025-10-272022Cureus, 2022; 14(7):e27369-1-e27369-62168-81842168-8184https://hdl.handle.net/2440/147999Sperm sorting procedures depend on centrifugation processes. These processes produce oxidative stress and cell damage that are undesirable for in-vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) outcomes because they affect fertilization and implantation chances. The microfluidic sperm selection technique has shown promise in this area. It can create a platform for isolating and manipulating goodquality sperm cells using diverse triggers such as mechanical factors, chemical agents, and temperature gradients. Furthermore, microfluidic platforms can direct sperm cells for IVF or sperm sorting by utilizing an approach that is passive or active. In this review, we explain the use of microfluidics technologies for sorting and arranging sperm cells for different purposes. We also discuss the use of microfluidics technology in selecting and assessing sperm parameters and how it affects male infertility.en© Copyright 2022 Olatunji et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.intracytoplasmic sperm injection (icsi); sperm sorting; in vitro fertilization; sperm selection; human sperm; assisted reproduction technology; microfluidic devicesJournal article10.7759/cureus.27369863085Olatunji, O. [0000-0003-3533-2454]