Gebremichael, L.G.Suppiah, V.Wiese, M.D.Mackenzie, L.Phillips, C.Williams, D.B.Roberts, M.S.2021-07-052021-07-052021Pharmacogenomics, 2021; 22(9):553-5711462-24161744-8042http://hdl.handle.net/2440/131071Although statins are effective in treating high cholesterol, adverse effects do occur with their use. Efficacy and tolerability vary among statins in different ethnic groups. Indigenous Australians have a high risk for cardiovascular and kidney diseases. Prescribing statins to Indigenous Australians with multi-morbidity requires different strategies to increase efficacy and reduce their toxicity. Previous studies have reported that Indigenous Australians are more susceptible to severe statin-induced myopathies. However, there is a lack of evidence in the underlying genetic factors in this population. This review aims to identify: inter-ethnic differences in the efficacy and safety of statins; major contributing factors accounting for any identified differences; and provide an overview of statin-induced adverse effects in Indigenous Australians.en© 2021 Future Medicine Ltd.Indigenousethnic groupspharmacogeneticssafetystatinJournal article100004230510.2217/pgs-2020-01520006611159000012-s2.0-85108150546578452Suppiah, V. [0000-0001-5496-935X]