Groth, C.Nornes, S.Mc Carty, R.Tamme, R.Lardelli, M.2007-05-112007-05-112002Development Genes and Evolution, 2002; 212(10):486-4900949-944X1432-041Xhttp://hdl.handle.net/2440/28202© Springer-Verlag 2002 The original publication can be found at www.springerlink.comPresenilins play prominent roles in the molecular pathogenesis of Alzheimer’s disease and during embryo development. We have isolated a zebrafish presenilin orthologue (pre2), which shows a high degree of sequence identity to the human PS2 protein. Zebrafish pre2 is maternally and ubiquitously expressed during early embryo development, whereas Pre2 protein expression is initiated between 6 and 12 hours post fertilisation (hpf), suggesting strict regulation of pre2 translation. pre2 expression is especially high in neural-crest-derived melanocytes.enPresenilinNeural crestZebrafishAlzheimer’s diseaseMelanocyteIdentification of a second presenilin gene in zebrafish with similarity to the human Alzheimer's disease gene presenilin2Journal article002002171810.1007/s00427-002-0269-50001797237000032-s2.0-003693584659709Lardelli, M. [0000-0002-4289-444X]