Edmonds, M.Graichen, F.Gardiner, J.Abell, A.2008-10-012008-10-012008Organic Letters, 2008; 10(5):885-8871523-70601523-7052http://hdl.handle.net/2440/47879Copyright © 2008 American Chemical SocietyA methodology for the enantioselective synthesis of α-fluorinated β²-amino acids has been developed from readily available carboxylic acids 3. Conversion to the Evan's oxazolidinone followed by enantioselective fluorination and alkylation gave 7 in high diastereomeric excess (>95%). Subsequent removal of the oxazolidinone and amination at the Bn-protected hydroxyl center gave optically active α-fluorinated β²-amino acids.enCarboxylic AcidsHydrocarbons, FluorinatedOxazolidinonesAmino AcidsMolecular StructureAminationCatalysisStereoisomerismEnantioselective synthesis of α-fluorinated β²-amino acidsEnantioselective synthesis of alpha-fluorinated beta(2)-amino acidsJournal article00200802952008100113205010.1021/ol703045z0002535196000512-s2.0-4354909246743728Abell, A. [0000-0002-0604-2629]