Jones, S.Jones, M.McNabb, S.Aitken, S.Coxon, J.Abell, A.2010-06-022010-06-022009Protein and Peptide Letters: international journal for rapid publication of short papers in protein and peptide science, 2009; 16(12):1466-14720929-86651875-5305http://hdl.handle.net/2440/58623A series of Val-Leu based peptidic aldehydes containing either a furan or thiophene at the Nterminus was prepared and assayed against ovine m-calpain. In general, potency is favoured by a 2- substituted (rather than 3-substituted) heterocycle, a thiophene rather than a furan, and a shorter chain length at the N-terminus. Molecular docking experiments provide some rationale for these observations.enCalpain inhibitorspeptidic aldehydessynthesisheterocyclesJournal article002009462310.2174/0929866097898392960002716202000092-s2.0-7344912762636235Abell, A. [0000-0002-0604-2629]