Craddock, C.Bardy, P.Kreiter, S.Johnston, R.Apperley, J.Marks, D.Huber, C.Kolbe, K.Goulding, R.Lawler, M.Goldman, J.Hughes, T.Derigs, G.2006-06-262006-06-262000British Journal of Haematology, 2000; 111(3):797-8000007-10481365-2141http://hdl.handle.net/2440/9330The definitive version may be found at www.wiley.comGraft-versus-host disease (GVHD) remains a significant complication in patients undergoing allogeneic stem cell transplantation (SCT) using a reduced intensity conditioning regimen. Although T-cell depletion (TCD) reduces the risk of GVHD after a myeloablative conditioning regimen, it is associated with an increased risk of graft failure. We have therefore examined whether TCD compromises engraftment using a fludarabine-based conditioning regimen. Fifteen patients have been transplanted using such a regimen of whom 13 underwent ex vivo TCD. All but one patient demonstrated durable engraftment and no patient receiving a TCD product developed severe GVHD. Thus, TCD may play a role in GvHD prophylaxis using such regimens.enT-LymphocytesHumansLeukemiaMultiple MyelomaGraft vs Host DiseaseLymphocyte DepletionTransplantation ConditioningHematopoietic Stem Cell TransplantationTransplantation, HomologousAdultAgedMiddle AgedFemaleMaleJournal article000100160210.1111/j.1365-2141.2000.02454.x2-s2.0-003449219263125Hughes, T. [0000-0002-0910-3730] [0000-0002-7990-4509]