Crott, Jimmy Walter2006-12-282006-12-2820012001http://hdl.handle.net/2440/21696Reprints of the author's previously published articles included as an appendix.Bibliography: leaves 165-188.xiv, 189 leaves : ill. (some col.) ; 30 cm."This thesis describes a series of experiments that aimed to investigate the effects of folic acid deficiency and defects in folate metabolism on chromosome damage rates in human lymphocytes. The accumulation of chromosome damage over time is an important issue because it is thought to contribute to the mechanism of ageing and the aetiology of diseases of age such as cancer and Alzheimer's disease."123614 bytesapplication/pdfenDiseases Causes and theories of causation.Cancer Age factors.Folic acid Metabolism.Thesis