Irvine, R.White, J.Head, R.2006-07-262006-07-261995Life Sciences, 1995; 56(13):1073-10780024-32051879-0631http://hdl.handle.net/2440/14498This study investigated the effects of captopril, hydralazine and losartan on the locomotor activity, tailflick and hot plate latencies in spontaneously hypertensive rats (SHR) and their genetic controls the Wistar-Kyoto rat (WKY). The increased hot plate latencies normally exhibited by the spontaneously hypertensive rat were reduced or abolished by captopril ( 95 mg/kg/day p.o.) and losartan (18 mg/kg/day p.o.) treatment, but were unaffected by hydralazine (19 mg/kg/day p.o.). There were no observable effects of any of the drugs on tailflick latencies or locomotor activity. The results highlight a potential role for angiotensin II in analgesia that is independent of blood pressure change.enCopyright © 1995 Elsevier Science Ltdspontaneously hypertensive ratanalgesiacaptoprillosartanJournal article0030003384001995051110.1016/0024-3205(95)00043-6A1995QJ790000032-s2.0-002893187167390Head, R. [0000-0002-1196-0926]