Ravindran, J.Blumbergs, P.Crompton, J.Pietris, G.Waddy, H.2007-06-022007-06-022001Journal of Neurology, Neurosurgery and Psychiatry, 2001; 70(6):787-7890022-30501468-330Xhttp://hdl.handle.net/2440/32702© 2001 by Journal of Neurology, Neurosurgery, and PsychiatryPathological changes are reported in the anterior visual pathways of a 41 year old man with complex partial seizures treated with vigabatrin who developed bilateral visual field constriction. There was peripheral retinal atrophy with loss of ganglion cells and loss of nerve fibres in the optic nerves, chiasm, and tracts. No evidence of intramyelinic oedema was seen. These findings suggest that the primary site of injury lies within the ganglion cells in the retina. The degree of atrophy seen would suggest that the visual field loss is irreversible.enVisual PathwaysRetinaHumansEpilepsy, Complex PartialVigabatrinAnticonvulsantsVisual FieldsAdultMaleJournal article002001098310.1136/jnnp.70.6.7870001693549000172-s2.0-003498451661662