Grooby, Warwick L.2006-12-282006-12-2819961996http://hdl.handle.net/2440/18890Erratum is pasted on back end paper.Bibliography: leaves 231-268.xv, 268 leaves : ill. (chiefly col.) ; 30 cm.This thesis examines the expression of cell adhesion molecules on both endothelial cells (ECs) and circulating leukocytes, and investigates the role of these molecules in renal allograft rejection. The aims of the study are to establish an ovine model of renal allograft transplantation, to generate monoclonal antibodies (mAbs) against ovine endothelial cell adhesion molecules, to examine the efficacy of the mAbs in prolonging the survival of the sheep renal allografts and to study the kinetics of expression of cell adhesion molecules (CAMs) during cellular activation 'in vitro' and 'in vivo' during the onset of allograft rejection.271974 bytesapplication/pdfenCell adhesion molecules.Kidneys Transplantation.Thesis