Wong, A.K.Vogrin, S.Klepstad, P.Rubio, J.Le, B.Philip, J.Somogyi, A.A.2025-04-162025-04-162024Pharmacogenomics, 2024; 25(14-15):579-5861462-24161462-2416https://hdl.handle.net/2440/144230Aims: To examine the associations between CYP2D6 and CYP3A4 polymorphisms, plasma oxycodone and metabolite concentrations, and oxycodone response (dose, pain scores, and adverse effects) in people with pain from advanced cancer. Patients & Methods: This multi-center prospective cohort study included clinical data, questionnaires (pain and adverse effects), and blood (pharmacokinetics, DNA). Negative binomial regression and logistic regression were used. Results: Within 33 participants, there were no differences in oxycodone response between CYP2D6 intermediate/poor metabolisers compared to normal metabolisers. Higher plasma noroxycodone and noroxycodone/oxycodone concentration ratios had higher odds of uncontrolled average pain (OR 2.44 (95%CI 1.00–5.95), p = 0.05 and OR 10.48 (95%CI 1.42–77.15), p = 0.02, respectively). Conclusions: There was no observed benefit in CYP2D6 genotyping in oxycodone response, however monitoring noroxycodone and oxymorphone concentrations warrant further examination.en© 2024 Crown Copyright in the Commonwealth of Australia. Department of Palliative Care. Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.advanced canceranalgesicsOpioidpalliative carepharmacogeneticsHumansNeoplasmsMorphinansOxycodoneCytochrome P-450 CYP2D6Analgesics, OpioidProspective StudiesDose-Response Relationship, DrugGenotypeAdultAgedMiddle AgedFemaleMaleCytochrome P-450 CYP3ACancer PainJournal article10.1080/14622416.2024.2430161723231Somogyi, A.A. [0000-0003-4779-0380]