Boyce, S.Nassar, N.Lee, C.Suen, M.Zahrani, S.Gladman, M.2018-04-262018-04-262016Medical Journal of Australia, 2016; 205(10):465-4700025-729X1326-5377http://hdl.handle.net/2440/111740Objective: Australia has the highest incidence of colorectal cancer (CRC) in the world. The incidence of young-onset CRC (yCRC) is increasing in developed nations. Our aim was to determine the incidence of yCRC in New South Wales, the demographic and clinico-pathological characteristics of these patients, and their survival. Design, setting, participants: A population-based cohort study of all cases of CRC diagnosed in NSW during 2001-2008. Data on newly diagnosed cases of CRC were obtained from the NSW Central Cancer Registry; mortality data were obtained from the NSW Registry of Births Deaths and Marriages (to 2012). The characteristics and tumour-related factors of patients under 50 years of age (yCRC) were compared with those for patients aged 50 years or more. Main outcome measures: Current incidence of yCRC and trends in incidence; 5-year cancer-specific survival rates and risks of death compared with older patients. Results: 32 178 patients were diagnosed with CRC, including 2001 (6.2%) with yCRC. The incidence of yCRC was unchanged across the study period (2001, 13.7 cases per 100 000 population; 2008, 11.8 per 100 000; P = 0.26). Rectal cancer was more frequent in yCRC than in older patients (34.4% v 26.0%), as was distant disease (21.2% v 15.3%). However, 5-year cancer-specific survival was greater for patients with yCRC (68.8%; 95% CI, 66.2-71.2%) than for older patients (66.3%; 95% CI, 65.6-67.0%; P < 0.001). Conclusions: The incidence of yCRC did not increase in NSW during 2001-2008. Despite more advanced disease at presentation, cancer-specific survival was better than for older patients with CRC.en© 2016 AMPCo Pty Ltd. Produced with Elsevier B.V. All rights reserved.HumansColorectal NeoplasmsMass ScreeningRegistriesIncidenceSurvival RateMultivariate AnalysisProportional Hazards ModelsCohort StudiesAge of OnsetAdultAgedAged, 80 and overMiddle AgedNew South WalesFemaleMaleKaplan-Meier EstimateJournal article003006859910.5694/mja16.002370003908488000242-s2.0-84996490868349006Gladman, M. [0000-0001-8412-9570]