Preparation of (–)-(7R)-7-acetyl-7-hydroxy-4,4-dimethoxy-5,6,7,8-tetrahydro-naphthalen-1(4H)-one, a chiral AB-synthon for anthracycline synthesis

Warrener, R.N.Gee, P.S.Russell, R.A.2014-10-072014-10-071981Journal of the Chemical Society, Chemical Communications, 1981; 1981(21):1100-11010022-4936http://hdl.handle.net/2440/85911The (–)-(R)-dienone (13) was prepared in 10 steps from the known 8-hydroxy-5-methoxy-2, 3-dihydronaphthalen-1(4H)-one (2), and the chirality at C(7) in (13) corresponds to that found at C(9) in the naturally occurring anthracyclines related to daunomycin.enCopyright status unknownPreparation of (–)-(7R)-7-acetyl-7-hydroxy-4,4-dimethoxy-5,6,7,8-tetrahydro-naphthalen-1(4H)-one, a chiral AB-synthon for anthracycline synthesisJournal article003000923710.1039/c39810001100A1981MP523000062-s2.0-37049097918102310