Cloke, D.Green, J.Khan, A.Hodgkinson, P.McLean, N.2006-06-262006-06-262004Journal of Plastic, Reconstructive and Aesthetic Surgery, 2004; 57(7):556-5601748-68150007-1226http://hdl.handle.net/2440/10549Wound infection following tissue transfer in head and neck oncology is common. Factors known to be associated with infective complications include blood transfusion, pre-operative radiotherapy, duration of surgery, duration of pre-operative stay and a history of smoking. The present study specifically examined 100 consecutive patients on a standard antibiotic protocol undergoing free flap reconstruction following resection of cancers of the oral cavity or oropharynx. Despite prophylactic antibiotics, 21 patients developed a head and neck wound infection. No statistically significant association was found between infective wound complications and a history of smoking, pre-operative radiotherapy or chemotherapy, length of pre-operative hospital stay, duration of surgery, or number of units of blood transfused. We conclude that, in this group of patients, wound infection is a common and difficult problem, but with no statistically significant association with any of the variables studied.enSurgical FlapsHumansStaphylococcal InfectionsSurgical Wound InfectionMouth NeoplasmsCefuroximeMetronidazoleDrug Therapy, CombinationPremedicationProspective StudiesAdultAgedAged, 80 and overMiddle AgedFemaleMalePlastic Surgery ProceduresJournal article002004194510.1016/j.bjps.2004.04.0060002236777000112-s2.0-434462315555925