Forbes, B.A.P.T. Patent and Trade Mark Attorneys2012-12-142012-12-142010http://hdl.handle.net/2440/74648PATENT: B. Forbes (Assignee: University of Adelaide). WO 2004/007543 A1 (PCT/AU2003/000898) filed Jul 11, 2003; published Jan 22, 2004Altered IGFBPs are able to bind IGF but the release is inhibited by resistance to protease cleavage and/or reduced binding to extracellular matrix (ECM). Alterations have been made in IGFBP-2 to the linker domain in particular and two amino acid motifs found to be important for ECM binding. IGF-1 mediated proliferation of cancer cells have been inhibited by the use of these altered IGFBPs.enWO 2004/007543 A1Patent0020114544455922226911