Luscombe-Marsh, N.Clifton, P.Noakes, M.Parker, B.Wittert, G.2006-06-262006-06-262002Diabetes Care, 2002; 25(4):652-6570149-59921935-5548http://hdl.handle.net/2440/9403Copyright © 2002 by the American Diabetes Association, Inc.Objective - To determine the effect of a high-protein (HP) diet compared with a low-protein (LP) diet on weight loss, resting energy expenditure (REE), and the thermic effect of food (TEF) in subjects with type 2 diabetes during moderate energy restriction. Research design and methods - In this study, 26 obese subjects with type 2 diabetes consumed a HP (28% protein, 42% carbohydrate) or LP diet (16% protein, 55% carbohydrate) during 8 weeks of energy restriction (1,600 kcal/day) and 4 weeks of energy balance. Body weight and composition and REE were measured, and the TEF in response to a HP or LP meal was determined for 2 h, at weeks 0 and 12. Results - The mean weight loss was 4.6 ± 0.4 kg (P < 0.001), of which 4.5 ± 0.4 kg was fat (P < 0.001), with no effect of diet (P = 0.6). At both weeks 0 and 12, TEF was greater after the HP than after the LP meal (0.064 vs. 0.050 kcal · kcal-1 energy consumed · 2 h-1, respectively; overall diet effect, P = 0.003). REE and TEF were reduced similarly with each of the diets (time effects, P = 0.02 and P < 0.001, respectively). Conclusions - In patients with type 2 diabetes, a low-fat diet with an increased protein-to-carbohydrate ratio does not significantly increase weight loss or blunt the fall in REE.enHumansDiabetes MellitusDiabetes Mellitus, Type 2ObesityBody WeightWeight LossDietary FatsDietary ProteinsBasal MetabolismBody CompositionEnergy MetabolismEnergy IntakeMiddle AgedFemaleMaleDiet, DiabeticJournal article002002034210.2337/diacare.25.4.6520001746353000022-s2.0-003654923360458Luscombe-Marsh, N. [0000-0001-9690-4722]Clifton, P. [0000-0002-6411-626X]Wittert, G. [0000-0001-6818-6065]