Strategies and methods for the attachment of amino acids and peptides to chiral [n]polynorbornane templates

Pfeffer, F.Russell, R.2008-10-302008-10-302003Organic and Biomolecular Chemistry, 2003; 1(11):1845-18511477-05201477-0539http://hdl.handle.net/2440/48107© The Royal Society of Chemistry 2003A versatile synthesis of amino acid and peptide functionalised [n]polynorbornane scaffolds is described. The frameworks are constructed using the stereoselective and regioselective cycloaddition of suitably functionalisedchiral cyclobutene epoxides with similar norbornenes. The strategies employed allow a range of topologies to be accessed and a number of regioselectively addressable linkage points to be accommodated.enNorbornanesAmino AcidsPeptidesCyclizationStereoisomerismStrategies and methods for the attachment of amino acids and peptides to chiral [n]polynorbornane templatesJournal article002008280910.1039/b301980b2-s2.0-003792686741888