Li, K.Paquet, C.Johnston, K.Williams, M.2025-12-172025-12-172016Respirology, 2016, vol.21, iss.2, pp.138-1323-77991440-1843https://hdl.handle.net/11541.2/122324Introduction/Aim: Intergenerational associations in COPD are well recognised and may result from genetic, gene-environment or exposure to life course factors. Consequently, children of parents with COPD pose a high risk group for development of COPD. We evaluated the reported prevalence of co-occurrence of COPD diagnosis in parents and offspring. Method: Five databases (Medline, Embase, Scopus, CINHL, Cochrane library) were searched for original, human studies where prevalence of COPD was reported in both offspring (children) and one or both parents. Studies were excluded if COPD was not defined (spirometry, physician diagnosis, self-report or symptom profile), parents or offspring were not reported separately to first degree relatives, COPD was combined with other chronic respiratory conditions, familial studies of alpha-1-antitrypsin (AAT) deficiency or not published in English. Data extraction was completed by two independent reviewers. Where possible, the odds ratio was calculated if it was not reported.Results: Of 3382 citations, 134 full texts were reviewed to include seven studies (3 case-control, 2 cross-sectional, 2 cohort) reflecting prevalence of COPD in offspring of people with COPD (n = 3) or prevalence of people with COPD reporting positive parental history of COPD (n = 4). The prevalence of COPD in offspring of people with COPD ranged from 6.6% (female aged 16-39) to 17.3% (males aged 16-39). The prevalence of people with COPD with a parental history of COPD ranged from 11.7% (adoptees non biological parents) to 58% (in people with severe, early onset COPD (non AAT)). The unadjusted odds ratio of an offspring having COPD if they have a parental history of COPD ranged from 1.21 to 7.9. Conclusion: There were surprisingly few studies that specifically reported prevalence of COPD in offspring of parents with COPD, with the resultant wide range of prevalence of co-occurrence of COPD likely to reflect specific, non-representative study samples.enCopyright 2016 Wiley-Blackwell PublishingConference item000373102400291Williams, M. [0000-0002-0473-5157]