Billing, K.Karagiannis, A.Selva-Nayagam, D.2009-12-222009-12-222003American Journal of Ophthalmology, 2003; 136(4):746-7470002-93941879-1891http://hdl.handle.net/2440/54991<h4>Purpose</h4>To report a case of punctal-canalicular stenosis after topical mitomycin C use for corneal dysplasia. To the authors' knowledge, this association has not previously been described.<h4>Design</h4>Observational case report.<h4>Method</h4>A 62-year-old woman was noted to have a right inferotemporal corneal dysplastic lesion. She received a topical course of mitomycin-C 0.04% four times a day, which subsequently invoked a toxoallergic reaction. One month later, the patient developed right-sided epiphora.<h4>Results</h4>Probing demonstrated complete stenosis of the right lower canaliculus, 5 mm from the punctum.<h4>Conclusion</h4>Mitomycin-C use may lead to lacrimal apparatus fibrosis and symptomatic epiphora when inciting a toxoallergic reaction.enNasolacrimal DuctHumansCorneal DiseasesLacrimal Duct ObstructionFibrosisMitomycinAntibiotics, AntineoplasticAdministration, TopicalMiddle AgedFemaleJournal article002009188110.1016/S0002-9394(03)00393-30001855385000252-s2.0-014157043238049Selva-Nayagam, D. [0000-0002-2169-5417]