Andrew, N.H.Kearney, D.Sladden, N.McKelvie, P.Wu, A.Sun, M.T.McNab, A.Selva, D.2018-11-192018-11-192016American Journal of Ophthalmology, 2016; 163:148-153.e10002-93941879-1891http://hdl.handle.net/2440/116167Purpose: To review the clinical and histologic features of idiopathic dacryoadenitis, and to assess prognostic factors associated with disease recurrence, treatment recalcitrance, and incomplete treatment response. Design: Retrospective interventional case series. Methods: setting: Tertiary referral centers. patients: Seventy-nine cases of biopsy-confirmed idiopathic dacryoadenitis. observation procedures: The following data were reviewed: age, sex, laterality, symptom onset, clinical presentation, histopathology, treatment response, and recurrence. main outcome measures: Rates of treatment recalcitrance, incomplete treatment response, and recurrence. Results: Idiopathic dacryoadenitis patients had a mean age of 50 years, 57% were female, and 16% of cases were bilateral. Fifty-two percent had inflammation extending to adjacent structures on imaging. Twenty percent were recalcitrant to treatment, 17% had an incomplete treatment response, and 15% of patients had a recurrence during a mean follow-up time of 64 months. Risk factors for an incomplete treatment response were male sex (P = .01) and inflammation extending to extraocular muscle (P = .01). A clinical presentation of "classic" dacryoadenitis was a risk factor for treatment recalcitrance (P = .02). Bilateral cases were younger than unilateral cases (P = .004) and had an increased risk of recurrence (P = .05). Sclerosing cases were associated with an insidious onset of symptoms (P = .009), but neither histopathology nor the speed of symptom onset was associated with a poor prognosis. Conclusion: Thirty-seven percent of idiopathic dacryoadenitis had a poor response to treatment and 15% of cases recurred. The prognostic factors identified in this study have not been reported previously and may inform management.en© 2016 Elsevier Inc. All rights reserved.Dacryocystitis; treatment outcomesJournal article003004180710.1016/j.ajo.2015.11.0320003714475000202-s2.0-849592074392-s2.0-84952056026226660Sun, M.T. [0000-0002-8066-9278]Selva, D. [0000-0002-2169-5417]