Rolan, Paul Edward2007-09-082007-09-0819951995http://hdl.handle.net/2440/38411Copies of author's previously published articles insertedDescribes the exploratory clinical development of tucaresol, consisting of three studies performed on humans and subsequent in vitro and animal studies investigating the possible effects on the immune system. Demonstrates that rational drug design may be an efficient way of selecting potential therapeutic candidates.xxi, 265 leaves103931 bytesapplication/pdfen615.7 615.19 20Antisickling agents Design.Drugs Structure-activity relationships.Pharmaceutical biotechnology.The exploratory clinical development of tucaresol, an antisickling agent, using a novel surrogate markerThesis