Bradfield, J.Taal, H.Timpson, N.Scherag, A.Lecoeur, C.Warrington, N.Hypponen, E.Holst, C.Valcarcel, B.Thiering, E.Salem, R.Schumacher, F.Cousminer, D.Sleiman, P.Jianhua, Z.Berkowitz, R.Vimaleswaran, K.Ivonne, J.Pennell, C.Evans, D.et al.2015-01-052015-01-052012Nature Genetics, 2012; 44(5):526-5311061-40361546-1718http://hdl.handle.net/2440/88481Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 × 10−6 in nine independent data sets (2,818 cases and 4,083 controls), we observed two loci that yielded genome-wide significant combined P values near OLFM4 at 13q14 (rs9568856; P = 1.82 × 10−9; odds ratio (OR) = 1.22) and within HOXB5 at 17q21 (rs9299; P = 3.54 × 10−9; OR = 1.14). Both loci continued to show association when two extreme childhood obesity cohorts were included (2,214 cases and 2,674 controls). These two loci also yielded directionally consistent associations in a previous meta-analysis of adult BMI.en© 2012 Nature America, Inc. All rights reserved.Early Growth Genetics ConsortiumHumansObesityGenetic Predisposition to DiseaseGenetic MarkersBody Mass IndexCase-Control StudiesPolymorphism, Single NucleotideAdolescentAdultGenome-Wide Association StudyYoung AdultGenetic LociJournal article002013661110.1038/ng.22470003034163000122-s2.0-8486035099915544