Wilson, D.Mattapallil, J.Lay, M.Zhang, L.Roederer, M.Davenport, M.2008-05-232008-05-232007Journal of Virology, 2007; 81(15):8025-80290022-538X1098-5514http://hdl.handle.net/2440/44836CD4+ T-cell depletion during acute human immunodeficiency virus infection occurs predominantly in the gastrointestinal mucosa. Using experimental data on SIV(mac251) viral load in blood and CD4+ T cells in the jejunum, we modeled the kinetics of CD4+ T-cell infection and death and estimated the viral infectivity. The infectivity of SIV(mac251) is higher than previously estimated for SHIV89.6P infection, but this higher infectivity is offset by a lower average peak viral load in SIV(mac251). Thus, the dynamics of target cell infection and death are remarkably similar between a CXCR4- and a CCR5-tropic infection in vivo.en© 2007, American Society for Microbiology. All Rights Reserved.Gastrointestinal TractCD4-Positive T-LymphocytesAnimalsMacaca mulattaHumansSimian Acquired Immunodeficiency SyndromeReceptors, CCR5Viral LoadMathematicsModels, TheoreticalSimian immunodeficiency virusJournal article002007685010.1128/JVI.01771-060002480274000212-s2.0-3454709547444662