Chirkov, Y.Holmes, A.Martelli, J.Horowitz, J.2006-06-262006-06-262004American Journal of Cardiology, 2004; 93(11):1438-14400002-91491879-1913http://hdl.handle.net/2440/9791Copyright © 2004 Excerpta Medica Inc. All rights reserved.In 15 patients with chronic heart failure of ischemic origin who were not previously treated with angiotensin-converting enzyme inhibitors, platelets exhibited hyperaggregability and impaired responsiveness to the antiaggregatory and cyclic guanosine monophosphate-stimulatory effects of nitric oxide donor sodium nitroprusside compared with normal subjects; this was paralleled by increased blood levels of superoxide radicals. Treatment with perindopril for 4 days significantly improved platelet responses to sodium nitroprusside; there was also a trend toward a decrease in superoxide radical levels.enHumansVentricular Dysfunction, LeftNitroprussideSuperoxidesNitric OxidePerindoprilCyclic GMPNitric Oxide DonorsAngiotensin-Converting Enzyme InhibitorsPlatelet Function TestsPlatelet AggregationTime FactorsMiddle AgedFemaleMaleHeart FailureJournal article002004053510.1016/j.amjcard.2004.02.0520002218151000272-s2.0-254244821156965Horowitz, J. [0000-0001-6883-0703]