Liu, Y.Yang, G.Baby, T.Tengjisi,Chen, D.Weitz, D.A.Zhao, C.X.2022-03-162022-03-162020Angewandte Chemie International Edition, 2020; 59(12):4720-47281433-78511521-3773https://hdl.handle.net/2440/134577International Edition. Version of record online: February 4, 2020Poor solubility often leads to low drug efficacy. Encapsulation of water-insoluble drugs in polymeric nanoparticles offers a solution. However, low drug loading remains a critical challenge. Now, a simple and robust sequential nanoprecipitation technology is used to produce stable drugcore polymer-shell nanoparticles with high drug loading (up to 58.5%) from a wide range of polymers and drugs. This technology is based on tuning the precipitation time of drugs and polymers using a solvent system comprising multiple organic solvents, which allows the formation of drug nanoparticles first followed by immediate precipitation of one or two polymers. This technology offers a new strategy to manufacture polymeric nanoparticles with high drug loading having good long-term stability and programmed release and opens a unique opportunity for drug delivery applications.en© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheimdrug loading; hydrophobic drugs; nanoprecipitation; polymer nanoparticlesJournal article10.1002/anie.2019135392022-03-16580285Liu, Y. [0000-0003-1320-139X]Yang, G. [0000-0002-6194-1918]