Jeffery, D.Perkins, M.White, J.2011-09-272011-09-272005Organic Letters, 2005; 7(8):1581-15841523-70601523-7052http://hdl.handle.net/2440/66396[reaction: see text] A short total synthesis of the putative structure of the marine natural product tridachiahydropyrone as a single enantiomer is described. Novel steps include a cuprate addition and cyclization to form a cyclohexanone ring and formation of the bicyclic pyrone with P(2)O(5) on Celite. The spectroscopic data obtained for compound 1 do not match those reported for tridachiahydropyrone; therefore, revision of the assigned natural product structure is warranted.enCopyright © 2005 American Chemical SocietyAnimalsMolluscaPyronesNuclear Magnetic Resonance, BiomolecularMolecular StructureCyclizationStereoisomerismJournal article002010535010.1021/ol050236d0002283442000372-s2.0-1784438757531223Jeffery, D. [0000-0002-7054-0374]