Pedersen, D.Abell, A.2011-10-132011-10-132011European Journal of Organic Chemistry, 2011; 2011(13):2399-24111434-193X1099-0690http://hdl.handle.net/2440/66714The ability to synthesise small peptidomimetics that mimic the secondary structure of proteins is an ever expanding area of research directed at sourcing new medicinal agents and biological probes. A significant current challenge is to mimic protein epitopes under physiological conditions using small peptidomimetics that are easy to prepare. The copper- and ruthenium-catalysed Huisgen cycloaddition reactions provide such a general synthetic method, with the resulting 1,2,3-triazoles being good peptide bond mimics. The ability to prepare both 1,4- and 1,5-substituted 1,2,3-triazoles under these chemically benign conditions provides both “linear” and “bent” peptidomimetics. Examples of the use of 1,2,3-triazoles to define the geometry and properties of a peptidomimetic abound. This review highlights such successes but also describes a number of failures in order to guide and inspire future efforts of chemists in this area.enCopyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, WeinheimCycloadditionClick chemistryPeptidomimeticsStructural BiologyProtein foldingJournal article002010565010.1002/ejoc.2011001570002896495000012-s2.0-7995461776531092Abell, A. [0000-0002-0604-2629]