Knights, K.McLean, C.Tonkin, A.Miners, J.2006-07-262006-07-261995British Journal of Clinical Pharmacology, 1995; 40(2):153-1560306-52511365-2125http://hdl.handle.net/2440/14328The effects of gender and oral contraceptive steroids on the pharmacokinetics of (R)-ibuprofen were studied in groups of healthy adult males, females and oral contraceptive steroid (OCS) using females. The values of AUC, CLpo, t1/2 and Vss, app did not differ significantly between the groups. Similarly, the percentage unbound of (R)-ibuprofen in pooled plasma from the three groups was not statistically different. Since chiral inversion is the major determinant of (R)-ibuprofen clearance in humans, it may be inferred from these data that gender and OCS have little or no effect on conversion of (R)-ibuprofen to the pharmacologically active S-enantiomer. Moreover, it is unlikely that hormonal factors influence the activity of the human hepatic long-chain fatty-acid:CoA ligase, the enzyme mediating the rate limiting step of (R)-ibuprofen inversion.enHumansIbuprofenContraceptives, Oral, HormonalAnti-Inflammatory Agents, Non-SteroidalAdministration, OralAnalysis of VarianceSex FactorsStereoisomerismAdolescentAdultFemaleMaleJournal article0030003438001995051410.1111/j.1365-2125.1995.tb05769.xA1995RN163000082-s2.0-002912321167444