González-Chica, D.Adams, R.Dal Grande, E.Avery, J.Hay, P.Stocks, N.2017-06-292017-06-292017Quality of Life Research, 2017; 26(6):1521-15300962-93431573-2649http://hdl.handle.net/2440/106331Published online: 11 February 2017Purpose: To investigate if sociodemographic characteristics increase the adverse effects of cardiovascular diseases (CVD) and cardiometabolic risk factors (CMRF) on health-related quality of life (HRQoL). Methods: Cross-sectional, face-to-face survey investigating 2379 adults living in South Australia in 2015 (57.1 ± 14 years; 51.7% females). Questions included diagnosis of CMRF (obesity, diabetes, hypertension, dyslipidaemia) and CVD. Physical and mental HRQoL were assessed using the SF-12v1 questionnaire. Multiple linear regression models including confounders (sociodemographic, lifestyle, use of preventive medication) and interaction terms between sociodemographic variables and cardiometabolic conditions were used in adjusted analysis. Results: The prevalence of CMRF (one or more) was 54.6% and CVD was 13.0%. The physical HRQoL reduced from 50.8 (95%CI 50.2-51.4) in healthy individuals to 45.1 (95%CI 44.4-45.9) and 39.1 (95%CI 37.7-40.5) among those with CMRF and CVD, respectively. Adjustment for sociodemographic variables reduced these differences in 33%, remaining stable after controlling for lifestyle and use of preventive medications (p < 0.001). Differences in physical HRQoL according to cardiometabolic conditions were twice as high among those with lower educational level, or if they were not working. Among unemployed, having a CMRF or a CVD had the same impact on the physical HRQoL (9.7 lower score than healthy individuals). The inverse association between cardiometabolic conditions and mental HRQoL was subtle (p = 0.030), with no evidence of disparities due to sociodemographic variables. Conclusions: A lower educational level and unemployment increase the adverse effects of cardiometabolic conditions on the physical HRQoL. Targeted interventions for reducing CMRF and/or CVD in these groups are necessary to improve HRQoL.en© Springer International Publishing Switzerland 2017Quality of lifeCardiovascular diseaseMetabolic diseaseSocioeconomic factorsHealth status disparitiesJournal article003006437310.1007/s11136-017-1503-y0004008352000142-s2.0-85012169801287322González-Chica, D. [0000-0002-7153-2878]Adams, R. [0000-0002-7572-0796]Dal Grande, E. [0000-0002-5919-3893]Avery, J. [0000-0002-8857-9162]Stocks, N. [0000-0002-9018-0361]