Wang, X.Xie, C.Marathe, C.S.Malbert, C.-H.Horowitz, M.Jones, K.L.Rayner, C.K.Sun, Z.Wu, T.2025-07-142025-07-142020Diabetes Research and Clinical Practice, 2020; 159:107951-1-107951-60168-82271872-8227https://hdl.handle.net/2440/145902Aims: Gastric emptying is a major determinant of postprandial glycaemia in both health and type 2 diabetes (T2DM); the potential impact of ethnicity on gastric emptying is unclear. We compared the rate of gastric emptying of a standardised meal and the associated glycaemic response in Han Chinese and Caucasian patients with T2DM. Methods: 14 Han Chinese and 14 Caucasian T2DM patients, managed by diet and/or metformin monotherapy, underwent concurrent measurements of gastric emptying and blood glucose for 240 min after a 99mTc-calcium phytate-labelled mashed potato meal. Results: Han Chinese patients were slightly younger (P < 0.05), and had a lower BMI (P < 0.05), than Caucasians. There were no differences in either HbA1c or fasting blood glucose between them. Gastric half-emptying time (T50) was shorter (P < 0.05) and the postprandial blood glucose increment greater (P < 0.05) in Han Chinese than Caucasian patients. Both the increment in blood glucose from baseline at 60 min and peak blood glucose were related inversely to T50 (P < 0.05 each). Conclusions: Han Chinese with relatively well-controlled T2DM have more rapid gastric emptying compared to Caucasians, which is associated with a greater postprandial glycaemic excursion. These differences may inform the choice of management, e.g. Han Chinese may particularly benefit from therapies that slow gastric emptying.en© 2019 Elsevier B.V. All rights reserved.Ethnicity; Gastric emptying; Postprandial glycaemia; Type 2 diabetesHumansDiabetes Mellitus, Type 2Gastric EmptyingPostprandial PeriodAdolescentAdultChildFemaleMaleHealthcare DisparitiesYoung AdultJournal article10.1016/j.diabres.2019.1079512024-05-06509266Xie, C. [0000-0002-0054-9269]Malbert, C.-H. [0000-0002-0665-4545]Horowitz, M. [0000-0002-0942-0306]Jones, K.L. [0000-0002-1155-5816]Rayner, C.K. [0000-0002-5527-256X]Wu, T. [0000-0003-1656-9210]