Stark, Z.Nisselle, A.McClaren, B.Lynch, F.Best, S.Long, J.C.Martyn, M.Patel, C.Schlapbach, L.J.Barnett, C.Theda, C.Pinner, J.Dinger, M.E.Lunke, S.Gaff, C.L.2019-09-042019-09-042019European Journal of Human Genetics, 2019; 27(10):1493-15011018-48131476-5438http://hdl.handle.net/2440/120873We investigated the attitudes of intensive care physicians and genetics professionals towards rapid genomic testing in neonatal and paediatric intensive care units (NICU/PICU). A mixed-methods study (surveys and interviews) was conducted at 13 Australian hospitals and three laboratories involved in multi-center implementation of rapid genomic testing. We investigated experience and confidence with genomic tests among intensivists; perceived usefulness of genomic diagnostic results; preferences for service delivery models; and implementation readiness among genetic services. The overall survey response rate was 59%, 47% for intensivists (80/170), and 75% (91/121) for genetics professionals. Intensivists reported moderate confidence with microarray tests and lower confidence with genomic tests. The majority of intensivists (77%), clinical geneticists (87%) and genetic counsellors (82%) favoured a clinical genetics-led service delivery model of genomic testing. Perceived clinical utility of genomic results was lower in the intensivist group compared to the genetics professionals group (20 v 50%, p < 0.001). Interviews (n = 6 intensivists; n = 11 genetic counselors) demonstrated support for implementation, with concerns relating to implementation environment and organizational readiness. Overall, our findings support initial implementation of genomic testing in NICU/PICU as part of an interdisciplinary service delivery model that promotes gradual adoption of genomics by the intensive care workforce while ensuring safety, sustainability, and efficiency.en© European Society of Human Genetics 2019.Genetic testing; paediatricsJournal article003012448610.1038/s41431-019-0429-y0004857816000032-s2.0-85066796317476187Barnett, C. [0000-0003-1717-3824]