Austin, C.Kahlert, J.Issa, F.Reed, J.Smith, J.Ioppolo, J.Ong, J.Jamie, J.Hibbs, D.Rendina, L.2015-12-172015-12-172014Dalton Transactions, 2014; 43(28):10719-107241477-92261477-9234http://hdl.handle.net/2440/97464Indoleamine-2,3-dioxygenase-1 (IDO1) is a critical immunoregulatory enzyme responsible for the metabolism of tryptophan during inflammation and disease. Based upon a pyranonaphthoquinone framework, the first examples of indoleamine-2,3-dioxygenase-1 (IDO1) inhibitors containing a carborane cage are reported. The novel closo-1,2-carboranyl-N-pyranonaphthoquinone derivatives display low μM binding affinity for the human recombinant enzyme, with IC50 values ranging from 0.78 to 1.77 μM.enCopyright the authorsBoron compoundsJournal article003002933810.1039/c4dt00444b0003384437000092-s2.0-84903464291172341Ong, J. [0000-0002-0958-460X]