Borg, M.J.Xie, C.Rayner, C.K.Horowitz, M.Jones, K.L.Wu, T.2021-10-072021-10-072021Nutrients, 2021; 13(8):2826-1-2826-142072-66432072-6643https://hdl.handle.net/2440/132457Postprandial hypotension (PPH) is an important and under-recognised disorder resulting from inadequate compensatory cardiovascular responses to meal-induced splanchnic blood pooling. Current approaches to management are suboptimal. Recent studies have established that the cardiovascular response to a meal is modulated profoundly by gastrointestinal factors, including the type and caloric content of ingested meals, rate of gastric emptying, and small intestinal transit and absorption of nutrients. The small intestine represents the major site of nutrient-gut interactions and associated neurohormonal responses, including secretion of glucagon-like peptide-1, glucose-dependent insulinotropic peptide and somatostatin, which exert pleotropic actions relevant to the postprandial haemodynamic profile. This review summarises knowledge relating to the role of these gut peptides in the cardiovascular response to a meal and their potential application to the management of PPH.en© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).Postprandial hypotension; glucagon-like peptide-1; glucose-dependent insulinotropic polypeptide; somatostatin; diabetes mellitus; autonomic failureHumansHypotensionDiabetes Mellitus, Type 2Gastric Inhibitory PolypeptideSomatostatinGlucagonInsulinBlood GlucoseAcarbosePeptidesGastrointestinal AgentsBlood PressureSplanchnic CirculationPostprandial PeriodGlucagon-Like Peptide 1Glucagon-Like Peptide-1 ReceptorJournal article10.3390/nu130828262021-10-07586242Borg, M.J. [0000-0002-4454-3651]Xie, C. [0000-0002-0054-9269]Rayner, C.K. [0000-0002-5527-256X]Horowitz, M. [0000-0002-0942-0306]Jones, K.L. [0000-0002-1155-5816]Wu, T. [0000-0003-1656-9210]